吴文惠(教授)

吴文惠，555050注册大白菜教授，博士生导师，浦江学者。中国生物化学与分子生物学学会海洋生物化学与分子生物学分会副理事长，中国药学会海洋药物专业委员会理事，上海市药学会海洋药物专业委员会副主任，中华医学会航海医学分会海洋生物工程专业委员会副主任。教学和科研领域生物制药专业和海洋药物化学学科。主持和参与完成多项生物与医药科研课题和生物制药专业本科教学改革项目。发表学术论文多篇，次大会报告研究成果，编著书籍多部，授权发明专利多项。指导大学生和研究生获得学士、硕士或博士学位。被授予555050注册大白菜优秀教育工作者、海洋科学技术奖、上海海洋科学技术奖等荣誉。

电话：021-61900388，Email：whwu@shou.edu.cn

一、主要承担教学情况

二、主要承担或参与课题

[1] 上海市创新行动计划，海洋胶原三维基质负载活性物质促进成骨细胞分化的研究.

[2] 国家自然科学基金，胶原促进骨稳态信号通路解析.

[3] 国家自然科学基金，海洋双吲哚纤溶化合物的结构修饰及其构效关系研究.

[4] 上海市创新行动计划，溶栓药物先导化合物毒理评价.

[5] 国家自然科学基金，海洋纤溶活性化合物影响纤溶因子生理作用特性研究.

[6] 科技部重大新药创制专项，胶原蛋白静电纺丝防水修复膜功效作用研究.

[7] 国家高技术发展计划，海洋微生物产生的纤溶活性化合物FGFC1成药性研究.

[8] 上海市自然科学基金，海洋纤溶活性化合物促进血栓溶解作用特性研究.

[9] 上海市浦江人才计划，微生物来源多萜酚化合物促进纤溶作用机制研究.

三、近期发表论文

[1] Jeevithan E, Jeyashakil R, Jingyi Z, Bin B, Nan M, José EM, Wenhui W.Collagen Peptide Upregulates Osteoblastogenesis from Bone Marrow Mesenchymal Stem Cells through MAPK- Runx2.Cells, 2019, 8(446): 1-15.

[2] Jeevithan E, Christelle S, José EM, Yves H, Shujun W, Keolebogile S Caroline MM, Ruihua G, Chunxiao W, Jeyashakila R, Joe MR, Bin B, Wenhui W. Cross-talk between primary osteocytes and bone marrow macrophages for osteoclastogenesis upon collagen treatment. Scientific Report, 2018, 4: 1-11.

[3] Jeevithan E, Yongshi B, Bao B, Jeyasekaran G, Jeyashakila R, Wenhui W. Effect of chemical and biological cross-linkers on mechanical and functional properties of shark catfish skin collagen films. Food Bioscience, 2017, 17:42-51.

[4] Yongshi B, Jeevithan E, Jingyi Z, Bin B, Ruihua G, Krishnamoorthy P, Jeyashakila R, Jeyasekaran G, Joe MR, Wenhui W. Immunological effects of collagen and collagen peptide from blue shark cartilage on 6T-CEM cells. Process Biochemistry, 2017, 57: 219-227. 

[5] Jeevithan E, Jingyi Z, Bin B, Krishnamoorthy P, Shujun Wang, Wenhui W. Rheological, biocompatibility and osteogenesis assessment of fish collagen scaffold for bone tissue engineering. International Journal of Biological Macromolecules, 2016, 91: 51-59.

[6] Jeevithan E, Jingyi Z, Bin B, Krishnamoorthy P, Shujun W, Wenhui W, Jeyashakila R. Rheological, biocompatibility and osteogenesis assessment of fish collagen scaffold for bone tissue engineering. International Journal of Biological Macromolecules, 2016, 91: 51-59.

[7] Jeevithan E, Jingyi Z, Bin B, JeyaShakila R, Wenhui W. Biocompatibility assessment of type-Ⅱ collagen and its polypeptide for tissue engineering: effect of collagen's molecular weight and glycoprotein content on tumor necrosis factor (Fas/Apo-1) receptor activation in human acute T-lymphocyte leukemia cell line. RSC Advances, 2016, 6: 14236–14246.

[8] Jingyi Z, Jeevithan E, Bin B, Zhang C, Kaili G, Shujun W, Wenhui W. Structural haracterization, in-vivo acute systemic toxicity assessment and in-vitro intestinal absorption properties of tilapia (Oreochromis niloticus) skin acid and pepsin solublilized type I collagen. Process Biochemistry, 2016, 51, 1891-2242.

[9] Jeevithan E, Jingyi Z, Nanping W, Lan H, Bin B, Wenhui W. Physico-chemical, antioxidant and intestinal absorption properties of whale shark type-Ⅱ collagen based on its solubility with acid and pepsin. Process Biochemistry, 2015, 50(3): 463-72.

[10] Jeevithan E, Bin B, Jingyi Z, Shaotong H, Wenhui W. Purification, characterization and antioxidant properties of low molecular weight collagenous polypeptide (37 kDa) prepared from whale shark cartilage (Rhincodon typus), Journal of Food Science and Technology, 2015, 52, 6312-6322.

[11] Jeevithan E, Jingyi Z, Nanping W, Lan H, Bin B, Wenhui W. Physico-chemical, antioxidant and intestinal absorption properties of whale shark type II collagen based on its solubility with acid and pepsin, Process Biochemistry, 2015, 50: 463–472.

[12] Jeevithan E, Jingyi Z, Bin B, Shanqiao C, Yongxin Y, Jeyashakila R, Wenhui W. Type Ⅱ collagen derived from marine environe: an extended review for its mechanism of action in oral tolerance and its biomarkers for the detection of arthritis disease in earlier stage. World Journal of pharmacy and pharmaceutical science, 2015, 4, 215-238.

[13] Jeevithan E, Bin B, Yongshi B, Yu Z, Qingbo Z, Wenhui W. Type II Collagen and Gelatin from Silvertip Shark (Carcharhinus albimarginatus) Cartilage: Isolation, Purification, Physicochemical and Antioxidant Properties. Marine Drugs, 2014, 12: 3852-3873.

[14] Jeevithan E, Wenhui W, Wang N, Lan H, Bin B. Isolation, purification and characterization of pepsin soluble collagenisol ated from silvertip shark (Carcharhinus albimarginatus) skeletaland head bone. Process Biochemistry, 2014, 49: 1767–1777.

[15] Jeevithan E, Qingbo Z, Bin B, Wenhui W. Biomedical and Pharmaceutical Application of Fish Collagen and Gelatin: A Review. Journal of Nutritional Therapeutics, 2013, 2: 218-227.

[16] Lijuan C, Bin B, Nanping W, Jing X, Wenhui W. Oral Administration of Shark Type Ⅱ Collagen Suppresses Complete Freund’s Adjuvant-Induced Rheumatoid Arthritis in Rats. Pharmaceuticals 2012, 5: 339-352.

[17] Ruihua Guo, Dong Duan, Shaotong Hong, Yu Zhou, Fang Wang，Shujun Wang，Wenhui Wu，Bin Bao. A marine fibrinolytic compound FGFC1 stimulating enzymatic kinetic parameters of a reciprocal activation system based on a single chain urokinase-type plasminogen activator and plasminogen. Process Biochemistry, 2018, 68: 190-196.

[18] Ying Yin, Qiang Fu, Wenhui Wu, Menghao Cai, Xiangshan Zhou, Yuanxing Zhang. Producing Novel Fibrinolytic Isoindolinone Derivatives in Marine Fungus Stachybotrys longispora FG216 by the Rational Supply of Amino Compounds According to Its Biosynthesis Pathway. Marine Drugs, 2017, 15:1-13.

[19] Ruihua Guo, Yiting Zhang, Dong Duan, Qiang Fu, Xiangyu Zhang, Xiaowei Yu, Shujun Wang, Bin Bao, Wenhui Wu. Fibrinolytic Evaluation of Compounds Isolated from a Marine Fungus Stachybotrys longispora FG216. Chinese Journal of Chemistry, 2016, 34: 1194-1198.  

[20] Ge Wang, Wenhui Wu, Quangang Zhu, Shiqing Fu, Xiaoyu Wang, Shaotong Hong, Ruihua Guo, Bin Bao. Identification and Fibrinolytic Evaluation of an Isoindolone Derivative Isolated from a Rare Marine Fungus Stachybotrys longispora FG216. Chinese Journal of Chemistry, 2015, 33: 1089-1095.

[21] Ting Yan, Wenhui Wu, Tongwei Su, Jiajie Chen, Quangang Zhu, Chaoyan Zhang, Xiaoyu Wang, Bin Bao. Effects of a novel marine natural product: pyrano indolone alkaloid fibrinolytic compound on thrombolysis and hemorrhagic activities in vitro and in vivo. Archives of pharmacal research, 2015, 38: 1530–1540.

[22] Tongwei Su, Wenhui Wu, Ting Yan, Chaoyan Zhang, Bin Bao. Pharmacokinetics and tissue distribution of a novel marine fibrinolytic compound in Wistar rat following intravenous administrations. Journal of Chromatography B, 2013, 942–94330: 77-82.

[23] Wenhui Wu, Keiji Hasumi, Hui Peng, Xichang Wang, Bin Bao. Fibrinolytic Compounds Isolated from a Brown Alga Sargassum fulvellum. Marine Drugs, 2009, 7: 85-94.

[24] 杨晶，钱士云，张本帅，姜胜男，吴文惠，包春玲，包斌.海洋纤溶活性化合物FGFC1和FGFC2影响血小板聚集特性的研究.中国海洋药物，2019,3:1-8. 

[25] 张本帅，姜胜男，杨晶，钱士云，马子宾，郭锐华，包斌，吴文惠. 溶栓候选药物双吲哚海洋生物碱FGFC1的转化特性. 555050注册大白菜学报, 2019, 4: 634-642.

[26] 钱士云,杨晶,张本帅,姜胜男,吴文惠,郭锐华,包春玲,包斌.海洋长孢葡萄穗霉菌生物合成纤溶活性化合物的研究.中国海洋药物, 2019, 3: 52-58.

[27] 宋瑞瑞, 包斌,卜永士, 王永先, 陈丽娟, 吴文惠.Ⅱ型胶原蛋白的热稳定性、圆二色性和红外光谱研究. 中国海洋药物, 2013, 32(01): 55-62.

[28] 康俊霞, 康永锋, 包斌, 陈志华, 谢晶, 吴文惠. Na⁺、Ca²⁺和pH值对鲸鲨皮胶原蛋白热变性温度的影响. 食品科学, 2011, 32(13): 66-70.

[29] 吴文惠, 张艳, 包斌, 李燕. 不同鲨鱼皮胶原蛋白的分离及其特性研究. 中国海洋药物, 2008, 2: 22-28.

[30] 吴文惠, 朱夕波, 包斌, 杨怀玉, 周培根, 张兴群, 曹张军, 缪辉南. 水鲨头皮胶原蛋白分离及其部分特性研究. 中华航海医学与高气压医学杂志, 2007, 4: 230-232.

四、近期获得专利

[1] 吴文惠，郭锐华，姜胜男，段东，包斌，周文靖.吡喃骈吲哚化合物的制备方法及其用途. 中国：ZL201710568099.9.2019-04-16. 

[2] 郭锐华，吴文惠，包斌，张依婷，王格，张朝燕. 一种吡喃骈吲哚类化合物及其制备方法和应用. 中国：ZL201510486160.6. 2017-06-16.

[3] 杨劲峰, 吴文惠, 高凯莉, 包斌. 一种利用鱿鱼扇形骨制备β-甲壳素的方法. 中国: 201510824633.9. 2018-11-06.

[4] 张朝燕, 缪志刚, 熊月丰, 吴文惠. 一种从草叶马尾藻中同步提取草叶马尾藻多糖和草叶马尾藻多酚的方法.中国：201510238875.X.2017-04-12.

[5] 吴文惠，石雨琦，冷静，金佳妮，陈志华，黄思慧. 海洋鱼皮胶原蛋白保湿抗衰老化妆品及其制备方法. 中国: ZL201010553485.9. 2013-09-18.

[6] 周培根，缪辉南，吴文惠，何培民，蔡春尔，李燕. 从鲨鱼皮分离纯化生物医药用胶原蛋白的方法. 中国: ZL200710040590.0. 2012-01-11.

五、主要奖励

[1] 自然资源部，海洋科学技术奖，一等奖，2019. 第一获奖人

[2] 上海市海洋湖沼学会，上海海洋科学技术奖，二等奖，2019.第一获奖人

[3] 国家海洋局，海洋科学技术奖，二等奖，2018.第一获奖人

六、主要编著

[1] 副主编. 生物药物. 中国医药科技出版社，2014，北京.

[2] 副主编. 海洋药物导论. 上海科学技术出版社, 2012, 上海.

[3] 主编.脑、精神疾病与药物作用机制.科学出版社，2010，北京.