郭锐华(副教授)

发布者:郝洁发布时间:2023-02-20浏览次数:4916

郭锐华,博士,副教授,硕士生导师,2011年于中国科学院昆明植物研究所获得博士学位,随后在中国人民解放军第二军医大学药学院从事博士后研究工作,2014年加入2023白菜网址官网大全。目前研究方向包括:基于药食同源植物/海洋微生物活性分子的发现、结构修饰和成药性评价,创新药和功能食品的研究开发。担任上海海洋药物专业委员会委员、中国生物化学与分子生物学学会海洋分会理事。主持科研和教改项目10余项,其中包括国家自然科学基金项目1项。在Bioorganic ChemistryEuropeanJournalofMedicinalChemistry等国际知名学术期刊上发表论文40余篇,授权专利6项,指导学生获得全国大学生生命科学竞赛(2021年,创新创业类)二等奖1项。


联系方式

 E-mailrhguo@shou.edu.cn


教学工作

目前承担的课程:

课程名称           学时  授课对象

药物化学            48     本科生

药物合成反应        48     本科生

药物合成反应实验    32     本科生

高等药物化学        16     研究生


科研项目

  1. ZSK植物中抗肿瘤活性成分的评价,2022.01-2025.12,主持。

  2. 海洋双吲哚化合物介于uPAR诱导纤溶酶原活化溶解血栓的调控机制研究,2022.01-2025.12,国家自然科学基金委员会,参与。

  3. 上海深渊生物圈前沿科学研究基地,2021.10-2026.09,上海市教育委员会,参与

  4.  ZSK植物中抗肿瘤活性成分的研究,2018.04-2019.12,主持。

  5. 2023白菜网址官网大全中青年人才培育项目,2018.04-2019.12,主持。

  6. 海洋双吲哚纤溶化合物的结构修饰及其构效关系研究,2016.01-2018.12,国家自然科学基金青年项目,主持。

  7. 基于毒理学评价的溶血栓药物先导化合物FGFC1临床前研究,2014.10-2017.09,上海市创新行动计划,参与。

  8. 海洋微生物代谢产物的分离、衍生化及纤溶活性研究,2015. 01-2016. 12,上海市校青年教师培养资助计划,主持。

  9. 海洋溶栓先导化合物FGFC2结构修饰与构效关系的研究,2014.09-2016.09555050注册大白菜博士科研启动,主持。

  10. 抗炎的倍半萜内酯IF-24的全合成及其构-效关系初探,2012. 01-2013. 12,中国博士后科学基金面上项目,主持。


代表论文

  1. Sijin Hang, Wenhui Wu, Yinan Wang, Ruilong Sheng, Yiwen Fang, Ruihua Guo.* Daphnetin, a Coumarin in Genus Stellera Chamaejasme Linn: Chemistry, Bioactivity and Therapeutic Potential. Chemistry Biodiversity2022, 19, e202200261.

  2. Sijin Hang; Hui Chen; Wenhui Wu; Shiyi Wang; Yiwen Fang; Ruilong Sheng; Qidong Tu;* Ruihua Guo.* Progress in Isoindolone Alkaloid Derivatives from Marine Microorganism: Pharmacology, Preparation, and Mechanism. Marine Drugs2022, 20, 405.

  3. Zhe Fu; Linjie Zhang; Sijin Hang; Shiyi Wang; Na Li; Xiaojing Sun; Zian Wang; Ruilong Sheng; Fang Wang; Wenhui Wu; Ruihua Guo.* Synthesis of Coumarin Derivatives: A New Class of Coumarin-Based G Protein-Coupled Receptor Activators and Inhibitors. Polymers2022, 14, 2021.

  4. Yuebin Liu, Ruilong Sheng, Junting Fan, Ruihua Guo.* A Review on Structure-Activity Relationships of Glycyrrhetinic Acid Derivatives with Diverse Bioactivities. Mini-Reviews in Medicinal Chemistry, 2022, 22, 2024-2066.

  5. Xiaojing Sun, Binyu Shen, Hui Yu, Wenhui Wu, Ruilong Sheng, Yiwen Fang, Ruihua Guo.* Therapeutic potential of demethylzeylasteral, a triterpenoid of the genus Tripterygium wilfordii, Fitoterapia, 2022, 163, 05333.

  6. Yinan Wang , Hui Chen, Ruilong Sheng , Zhe Fu, Junting Fan, Wenhui Wu, Qidong Tu,*Ruihua Guo,* Synthesis and Bioactivities of Marine Pyran-Isoindolone Derivatives as Potential Antithrombotic Agents, Marine Drugs2021, 19, 218.

  7. Yinan Wang, Jiangming Wang, Zhe Fu, Ruilong Sheng, Wenhui Wu, Junting Fan, Ruihua Guo,* Syntheses and evaluation of daphnetin derivatives as novel G protein-coupled receptor inhibitors and activators, Bioorganic Chemistry2020, 104, 104342.

  8. Jiangming Wang, Silei Lu, Ruilong Sheng, Junting Fan, Wenhui Wu and Ruihua Guo,* Structure-Activity Relationships of Natural and Synthetic Indole-Derived Scaffolds as α-Glucosidase Inhibitors: A Mini-Review, Mini-Reviews in Medicinal Chemistry 2020, 20, 1791-1818.

  9. Changhao Bian, Jiangming Wang, Xinyi Zhou, Wenhui Wu,* and Ruihua Guo*. Recent Advances on Marine Alkaloids from Sponges, Chemistry & Biodiversity 2020, 17, e2000186.

  10. Silei Lu, Jiangming Wang, Ruilong Sheng, Yiwen Fang, and Ruihua Guo*, Novel Bioactive Polyketides Isolated from Marine Actinomycetes: An Update Review from 2013 to 2019, Chemistry & Biodiversity2020, 17, e2000562.

  11. Yang Zhang, Kai Cheng, Bingwei Xu, Junfeng Shi, Jun Qiang, Shunjin Shi, Yuanqin Yi, Hongxia Li, Tengchuan Jin, Ruihua Guo, Yadi Wu, Zeyi Liu, Xiaowei Wei*, Jian-An Huang* and Xiuwei H. Yang*, Epigenetic Input Dictates the Threshold of Targeting of the Integrin-Dependent Pathway in Non-small cell Lung Cancer. Frontiers in Cell and Developmental Biology2020, 8, 652.

  12. Jiangming Wang, Changhao Bian, Yinan Wang, Quan Shea, Bin Bao, Junting Fan, Aixue Zuo*, Wenhui Wu*, Ruihua Guo*. Syntheses and bioactivities of songorine derivatives as novel G proteincoupled receptor antagonists, Bioorganic & Medicinal Chemistry, 2019, 27, 1903.

  13. Jiangming Wang, Siyuan Su, Shangzhe Zhang, Shiyang Zhai, Ruilong sheng, Wenhui Wu, Ruihua Guo*. Structure-activity relationship of α-santonin derivatives with diverse bioactivities: a mini-review, EuropeanJournal of Medicinal Chemistry, 2019, 175, 215.

  14. Ruihua Guo, Dong Duan, Shaotong Hong, Yu Zhou, Fang Wang, ShujunWang, Wenhui Wu*, Bin Bao*. A Marine Fibrinolytic Compound FGFC1 Stimulating Enzymatic Kinetic Parameters of A Reciprocal Activation System Based on a Single Chain Urokinase-type Plasminogen Activator and Plasminogen, Process Biochemistry, 2018, 68, 190.

  15. Ruihua Guo, Chengxin Guo, Dan He, Dake Zhao, Yong Shen*. Two New C-19-Diterpenoid Alkaloids with Anti-inflammatory Activity from Aconitum iochanicum. Chinese Journal Chemistry, 2017, 35, 1644.

  16. Ruihua Guo, Yiting Zhang, Dong Duan, Qiang Fu, Xiangyu Zhang, Xiaowei Yu, Shujun Wang, Bin Bao*, Wenhui Wu*. Fibrinolytic Evaluation of Compounds Isolated from a Marine Fungus Stachybotrys longispora FG216. Chinese Journal Chemistry, 2016, 34, 1194.

  17. Ge Wang; Wenhui Wu; Quangang Zhu; Shiqing Fu; Xiaoyu Wang; Shaotong Hong; Ruihua Guo*; Bin, Bao* Identification and Fibrinolytic Activity of an Indolone Derivative Isolated from a Rare Marine Fungus Stachybotrys longispora FG216. Chinese Journal Chemistry, 2015, 33, 10891095.


申请专利

  1. 郭锐华,王江茗,乔武,吴文惠. 宋果灵衍生物及其药物组合物和用途,发明专利,20225月,授权号ZL201910183030.3.

  2. 郭锐华,王易男,吴文惠,付哲. 抑制剂瑞香素衍生物及其药物组合物和应用,2022年,8月,授权号ZL202010916474.6.

  3. 郭锐华,王易男,吴文惠,付哲. 激动剂瑞香素衍生物及其药物组合物和应用,20228月,授权号ZL202010916486.9.

  4. 郭锐华,段东,钱士云,包斌,张朝燕,吴文惠. 极地海洋微生物产生的几种溶栓化合物的制备方法及用途,ZL201710823626.6.

  5. 吴文惠,郭锐华,姜胜男,段东,包斌,周文靖. 喃骈吲哚化合物及其制备方法和应用. 发明专利. 申请时间:2017年 授权时间2019. ZL201710568099.9.

  6. 郭锐华,吴文惠,包斌,张依婷,王格,张朝燕,一种吡喃骈吲哚化合物及其制备方法和应用,ZL201510486160.6


荣誉获奖

2022年爱普奖教金,一等奖

2022年上海药学科技奖,二等奖

2021年555050注册大白菜教学成果奖,一等奖

2019年度海洋科学技术奖,一等奖

2019年获得上海海洋科技术奖,二等奖

2018年获得国家海洋局海洋科学技术奖,二等奖

2015年获得555050注册大白菜教学成果,二等奖


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